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The National Alliance of Advocates
for Buprenorphine Treatment

Buprenorphine (Suboxone®, Subutex®3, Zubsolv®4, Bunavail™5, Probuphine®6) is an opioid medication used to treat opioid addiction in the privacy of a physician's office.1 Buprenorphine can be dispensed for take-home use, by prescription.1 This, in addition to the pharmacological and safety profile of buprenorphine, makes it an attractive treatment for patients addicted to opioids.2


Opioids are a family of drugs consisting of those derived from opium and of those synthesized in a lab to emulate the effects of opium.

The classification is more determined by the effects on the brain than to the specific chemistry of the substance. For example Methadone is a synthetic opioid. Chemically it is very different than heroin (another opioid); however, the effects on the brain are similar enough for both to be termed opioids, both cause a response at the opioid receptor.

Endorphins are opioids that occur naturally in the body. When humans experience feelings of joy, endogenous opioids are released which cause feelings of happiness and reduce pain. In a healthy human the amounts of endogenous opioids are regulated so that the person never becomes too euphoric or is in too much pain. When external opioids are introduced, the same feelings are experienced, however, at a greater level than can be experienced naturally.

Early on, people found opium had these properties, and it was used for medication for almost any condition found unpleasant. It was discovered that there could always be an appropriate dose that would alleviate any degree of suffering, at least for a short time. This miracle plant was often referred to in ancient literature as “plant of joy” and later as “God’s own medicine”.

<< Introduction     |     Opiates/Opioids >>

The Purpose of Buprenorphine Treatment:

To suppress the debilitating symptoms of cravings and withdrawal, enabling the patient to engage in therapy, counseling and support, so they can implement positive long-term changes in their lives which develops into the new healthy patterns of behavior necessary to achieve sustained addiction remission. - explain -

The National Alliance of Advocates for Buprenorphine Treatment is a non-profit organization charged with the mission to:

  1. U.S. Food and Drug Administration, FDA Talk Paper, T0238, October 8, 2002, Subutex and Suboxone approved to treat opiate dependence.
  2. Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Treatment Improvement Protocol (TIP) Series 40. DHHS Publication No. (SMA) 04-3939. Rockville, Md: Substance Abuse and Mental Health Services Administration, 2004.
  3. Subutex Discontinued in the US market in late 2011.
  4. Zubsolv (bup/nx sublingual tablet) FDA approved 7/3/2013 see buprenorphine pipeline graphic -in pharmacies now.
  5. Bunavail (bup/nx bucal film) FDA approved 6/6/2014 see buprenorphine pipeline graphic -in pharmacies now.
  6. Probuphine FDA approved 5/26/2016 - FDA Probuphine press release